Agent nonsedating antihistamine

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In addition to this antihistamine effect, they can have parallel pharmacological properties, for example antimuscarinic and adrenolytic effects which must be considered.It is usual to classify H1-antihistamines into two classes: old ones, called first-generation agents, which are sedating and recent ones, called second-generation agents which have slight or no sedating effects because they do not cross the blood-brain barrier.GPnotebook stores small data files on your computer called cookies so that we can recognise you and provide you with the best service.If you do not want to receive cookies please do not use GPnotebook.The drug to use in severe situations is adrenaline The early H1-antihistamines usually induce drowsiness and their prescription to patients with an activity requiring a normal vigilance, like control of a vehicle, is contra-indicated.By their alpha-adrenolytic effect especially when they are given by parenteral route, they could reduce the vasoconstrictive effect of adrenaline, administered for example in case of anaphylactic shock.

H1-antihistamines have been used for more than fifty years in treating various allergic manifestations. H1-antihistamines which penetrate into brain elicit, by inhibiting stimulant effect of histamine, drowsiness.In addition, each compound can have or not have parallel properties, antimuscarinic effects for example.This distinction between generations must be taken with caution because a product considered as non sedative or not antimuscarinic can, in certain circumstances, large doses or particular susceptibility of the patient ,have these effects.Mequitazine has an antimuscarinic effect parallel to its H1-antihistamine activity, which can result for example in dryness of mouth or accommodation disturbances.Loratadine acts mainly via one of its metabolites, decarboethoxyloratadine, also called desloratadine, which is also marketed.

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